Publikationen

Publikationen (peer reviewed)

2017

A chip-integrated optical microfluidic pressure sensor
C. Hoera, A. Kiontke, M. Pahl, D. Belder, Sensors and Actuators B: Chemical 2017, https://doi.org/10.1016/j.snb.2017.08.195

Liquid beam desorption mass spectrometry for the investigation of continuous flow reactions in microfluidic chips
S. Schulze, M. Pahl, F. Stolz, J. Appun, B. Abel, C. Schneider, D. Belder, Anal. Chem. 2017, 89, 6175–6181

A Highly Stereoselective Synthesis of Tetrahydrofurans
J. Appun, M. Boomhoff, P. Hoffmeyer, I. Kallweit, M. Pahl, D. Belder, C. Schneider, Angew. Chem. Int. Ed. 2017, 24, 6862-6865

A droplet-chip / mass spectrometry approach to study organic synthesis at nanoliter scale
J. R. Beulig, R. Warias, J. J. Heiland, S. Ohla, K. Zeitler, D. Belder, Lab Chip 2017, 17, 1996-2002

Temperature gradient elution and superheated eluents in chip-HPLC
J. J. Heiland, C. Lotter, V. Stein, L. Mauritz, D. Belder, Anal. Chem. 2017, 89, 3266–3271

On-chip integration of organic synthesis and HPLC/MS analysis for monitoring stereoselective transformations at the micro-scale
J. J. Heiland , R. Warias , C. Lotter , P. Fuchs , L. Mauritz , K. Zeitler , S. Ohla, D. Belder, Lab Chip 2017, 17, 76-81

Microchip HPLC separations monitored simultaneously by coherent anti-Stokes Raman scattering and fluorescence detection
D. Geissler, J. J. Heiland, C. Lotter, D. Belder, Microchim Acta 2017, 184, 315-321

 

2016

Enantioselective reaction monitoring utilizing two-dimensional heart-cut liquid chromatography on an integrated microfluidic chip
C. Lotter, E. Poehler, J. J. Heiland, L. Mauritz, D. Belder, Lab Chip 2016, 16, 4648-4652

Evaluation of Pressure Stable Chip-to-Tube Fittings Enabling High-Speed Chip-HPLC with Mass Spectrometric Detection
C. Lotter, J. J. Heiland, V. Stein, M. Klimkait, M. Queisser, D. Belder, Anal. Chem. 2016, 88, 7481–7486

Integrated on-chip mass spectrometry reaction monitoring in microfluidic devices containing porous polymer monolithic columns
C. Dietze, S. Schulze, S. Ohla, K. Gilmore, P. Seeberger, D. Belder, Analyst 2016, 141, 5412-5416

Chip-based electrochromatography coupled to ESI-MS detection
C. Dietze, C. Hackl, R. Gerhardt, S. Seim, D. Belder, Electrophoresis 2016, 37, 1345-1352

HPLC-MS with Glass Chips Featuring Monolithically Integrated Electrospray Emitters of Different Geometries
C. Lotter, J. J. Heiland, S. Thurmann, L. Mauritz, D. Belder, Anal. Chem. 2016, 88, 2856–2863

Analysis of Enantioselective Biotransformations Using a Few Hundred Cells on an Integrated Microfluidic Chip
K. M. Krone, R. Warias, C. Ritter, A. Li, C. G. Acevedo-Rocha, M. T. Reetz, D. Belder, JACS 2016, 138, 2102–2105

A chip-integrated highly variable thermal flow rate sensor
C. Hoera, M. M. Skadell, S. A. Pfeiffer, M. Pahl, Z. Shu, E. Beckert, D. Belder, Sensors and Actuators B: Chemical 2016, 225, 42-49

 

2015

Rapid prototyping of microfluidic chips for dead-volume-free MS coupling
C. Dietze, T. Scholl, S. Ohla, J. Appun, C. Schneider, D. Belder
Anal. Bioanal. Chem. 2015, 407, 8735-8743

Two-photon excitation in chip electrophoresis enabling label-free fluorescence detection in non-UV transparent full-body polymer chips
D. Geissler, D. Belder, Electrophoresis 2015, 36, 2976-2983

Fast electrically assisted regeneration of on chip SERS substrates
T. A. Meier, E. Poehler, F. Kemper, O. Pabst, H. G. Jahnke, E. Beckert, A. Robitzki, D. Belder, Lab Chip 2015, 15, 2923-2927

Chip-Based High-Performance Liquid Chromatography for High-Speed Enantioseparations
S. Thürmann, C. Lotter, J. J. Heiland, B. Chankvetadze, D. Belder, Anal. Chem. 2015, 87, 5568–5576

Chip-Based Free-Flow Electrophoresis with Integrated Nanospray Mass-Spectrometry
C. Benz, M. Boomhoff, J. Appun, C. Schneider, D. Belder, Angew. Chem. Int. Ed. 2015, 54, 2766-2770

On-chip monitoring of chemical syntheses in microdroplets via surface-enhanced Raman spectroscopy
T. A. Meier, R. J. Beulig, E. Klinge, M. Fuss, S. Ohla, D. Belder, Chem. Commun. 2015, 51, 8588-8591

An integrated microfluidic chip enabling control and spatially resolved monitoring of temperature in micro flow reactors
C. Höra, S. Ohla, Z. Shu, E. Beckert, S. Nagl, D. Belder, Anal. Bioanal. Chem. 2015, 407, 387-396

Surface modification of PDMS microfluidic devices by controlled sulfuric acid treatment and the application in chip electrophoresis
L. Gitlin, P. Schulze, S. Ohla, H.J. Bongard, D. Belder, Electrophoresis 2015, 36, 449-456

 

2014

High-performance liquid chromatography on glass chips using precisely defined porous polymer monoliths as particle retaining elements
S. Thürmann, L. Mauritz, C. Heck, D. Belder, J. Chromatogr. A 2014,
1370, 33-39

Phase-optimized chip-based liquid chromatography
S. Thürmann, D. Belder, Anal. Bioanal. Chem. 2014, 406, 6599-6606

Rapid Prototyping of Electrochromatography Chips for Improved Two-Photon Excited Fluorescence Detection
C. Hackl , R. Beyreiss , D. Geissler , S. Jezierski, D. Belder, Anal. Chem. 2014, 86, 3773–3779

A low pressure on-chip injection strategy for high-performance chip-based chromatography
S. Thurmann, A. Dittmar, D. Belder, J. Chromatogr. A 2014, 1340, 59–67

Improving sensitivity in microchip electrophoresis coupled to ESI-MS/MS on the example of a cardiac drug mixture
F. Schwarzkopf, T. Scholl, S. Ohla, D. Belder, Electrophoresis 2014, 35, 1880-1886

 

2013

Integrating continuous microflow reactions with subsequent micropreparative separations on a single microfluidic chip
S. Jezierski, V. Tehsmer,  S. Nagl,  D. Belder, Chem. Commun. 2013, 49, 11644-11646

Label-free fluorescence detection of aromatic compounds in chip electrophoresis applying two photon excitation and time-correlated single photon counting
R. Beyreiss, D. Geißler, S. Ohla, S. Nagl, T. N. Posch, D. Belder, Anal. Chem. 201385, 8150-8157

Micro flow reactor chips with integrated luminescent chemosensors for spatially resolved on-line chemical reaction monitoring 
L. Gitlin, C. Hoera, R. J. Meier, S. Nagl, D. Belder, Lab Chip 2013, 13, 4134-4141

Protein–protein interaction analysis in single microfluidic droplets using FRET and fluorescence lifetime detection
C. Benz, H. Retzbach, S. Nagl,  D. Belder, Lab Chip 2013, 13, 2808-2814

Towards an integrated device that utilizes adherent cells in a micro-free-flow electrophoresis chip to achieve separation and biosensing 
S. Jezierski, A.S. Klein, C. Benz, M. Schaefer, S. Nagl,  D. Belder, Anal. Bioanal. Chem. 2013, 5381-5386

Microfluidic free-flow electrophoresis chips with an integrated fluorescent sensor layer for real time pH imaging in isoelectric focusing
S. Jezierski ,  D. Belder, S. Nagl, Chem. Commun. 2013, 49, 904-906

Crossing the Border towards Deep UV Time-Resolved Microscopy of Native Fluophores
M. Koenig, S. Tannert, T. Schoenau, K. Lauritsen, F. Koberling, R. Erdmann, R. Beyreiss, S. Nagel, D. Belder, Biophysical Journal 2013104, 667A-667A

 

2012

Chip-based separation devices coupled to mass spectrometry 
S. Ohla, D, Belder, Current Opinion in Chemical Biology 2012, 16, 453–459

Monitoring on-Chip Pictet-Spengler Reactions by Integrated Analytical Separation and Label-Free Time-Resolved Fluorescence
S. Ohla,  R. Beyreiss, S. Fritzsche, P. Glaser, S. Nagl, K. Stockhausen, C. Schneider,  D. Belder*, Chem. Eur. J. 201218, 1240 – 1246

Label-free real-time imaging in microchip free-flow electrophoresis applying high speed deep UV fluorescence scanning
S. Köhler, S. Nagl, S. Fritzsche, D. Belder*, Lab Chip 2012, 12, 458-463

Micro free-flow electrophoresis with injection molded chips
S. Köhler, C. Benz, H. Becker, E. Beckert, V. Beushausen D. Belder*, RSC Adv. 2012, 2, 520-525

Poly(ethylene glycol)-coated microfluidic devices for chip electrophoresis
M. Schulze, D. Belder*, Electrophoresis 2012, 33, 370–378

 

2011

Label-free analysis in chip electrophoresis applying deep UV fluorescence lifetime detection
R. Beyreiss, S. Ohla, S. Nagl, D. Belder*, Electrophoresis 2011, 32, 3108–3114

Multistep liquid-phase lithography for fast prototyping of microfluidic free-flow-electrophoresis chips
S. Jezierski, L. Gitlin, S. Nagl, D. Belder*, Anal. Bioanal. Chem. 2011, 401, 2651–2656

Asymmetric Organocatalysis and Analysis on a Single Microfluidic Nanospray Chip
S. Fritzsche, S. Ohla, P. Glaser, D.S. Giera, M. Sickert, C. Schneider, D. Belder*, Angew. Chem. Int. Ed. 2011, 50, 9467 –9470

Microfluidic chips for chirality exploration 
S. Nagl, P. Schulze, S. Ohla, R. Beyreiss, L. Gitlin, D. Belder*, Anal. Chem. 2011, 83, 3232–3238

Rapid quantitative determination of ephedra alkaloids in tablet formulations and human urine by microchip electrophoresis
D. Belder*, K. Tolba, S. Nagl, Electrophoresis 2011, 32, 440-447

Chip electrophoresis of active banana ingredients with label-free detection utilizing deep UV native fluorescence and mass spectrometry 
S. Ohla, P. Schulze, S. Fritzsche, D. Belder*, Anal. Bioanal. Chem. 2011, 399, 1853-1857

PDMS free-flow electrophoresis chips with integrated partitioning bars for bubble segregation 
S. Köhler, C. Weilbeer, S. Howitz, H. Becker, V. Beushausen, D. Belder*, Lab Chip 2011, 11, 309-314

 

2010

An integrated on-chip sirtuin assay
S. Ohla, R. Beyreiss, G.K E. Scriba, Y. Fan, D. Belder*,  Electrophoresis 2010, 31, 3263-3267

Screening in One Sweep using the Slipchip
D. Belder, Angew. Chem. Int. Ed. 2010, 49, 6484–6486

A New Weakly Basic Amino-Reactive Fluorescent Label for Use in Isoelectric Focusing and Chip Electrophoresis
P. Schulze, M. Link, M. Schulze, S. Thuermann, O.S. Wolfbeis, D. Belder, Electrophoresis 201031, 2749–2753

Chip electrophoresis with mass spectrometric detection in record speed
S. Fritzsche, P. Hoffmann D. Belder*, Lab Chip 2010, 10, 1227–1230

 

2009

Spray Performance of Microfluidic Glass Devices with Integrated Pulled Nanoelectrospray Emitters
P. Hoffmann, M. Eschner, S. Fritzsche, D. Belder*, Anal. Chem. 2009, 81, 7256-7261

Progress in microchip enantioseparations
S. Nagl, P. Schulze, M. Ludwig  D. Belder*, Electrophoresis 2009, 30, 2765-2772

Towards an Integrated Chemical Circuit
D. Belder, Angew. Chem. Int. Ed. 2009, 48, 3736–3737

New diode laser-excitable green fluorescent label and its application to detection of bovine serum albumin via microchipelectrophoresis, 
M. Link, P. Schulze, D. Belder*, O. Wolfbeis*, Microchim. Acta 2009, 166, 183-188

Label-free fluorescence detection for capillary electrophoresis and microfluidic chip-based techniques
P. Schulze, D. Belder*, Anal. Bioanal. Chem. 2009, 393, 515-525

Rapid replication of master structures by double casting with PDMS
L. Gitlin, P. Schulze, D. Belder*, Lab Chip 2009, 9, 3000-3002


2008

Impact of laser excitation intensity on deep UV fluorescence detection in microchip electrophoresis
P. Schulze, M. Ludwig, D. Belder, Electrophoresis 2008, 29, 4894-4899

2007

Fast quantitative determination of diuretic drugs in tablets and human urine by microchip electrophoresis with native fluorescence detection
K. Tolba, D. Belder, Electrophoresis 2007, 28, 2934-2941

Microfluidic glass chips with an integrated nanospray emitter for coupling to a mass spectrometer
P. Hoffmann, U. Haeusig, P. Schulze, D. Belder, Angew. Chem. Int. Ed. 2007, 46, 4913-4916

Two-photon excited fluorescence detection at 420 nm for label-free detection of small aromatics and proteins in microchip electrophoresis
P. Schulze, M. Schuettpelz, M. Sauer, D. Belder, Lab Chip 2007, 7, 1841-1844

2006

Coating of powder-blasted channels for high-performance microchip electrophoresis
D. Belder, F. Kohler, M. Ludwig, K. Tolba, N. Piehl, Electrophoresis 2006, 27, 3277-3283

Integrating chemical synthesis and analysis on a chip
D. Belder, Anal. Bioanal. Chem. 2006, 385, 416-418

Enantioselective catalysis and analysis on a chip
D. Belder, M. Ludwig, L.W. Wang, M.T. Reetz, Angew. Chem. Int. Ed. 2006, 45, 2463-2466

2005

Deep UV laser-induced fluorescence detection of unlabeled drugs and proteins in microchip electrophoresis
P. Schulze, M. Ludwig, F. Kohler, D. Belder, Analytical Chemistry 2005, 77, 1325-1329

Microfluidics with droplets
D. Belder, Angew. Chem. Int. Ed. 2005, 44, 3521-3522

2004

Subsecond chiral separations on a microchip
N. Piehl, M. Ludwig, D. Belder, Electrophoresis 2004, 25, 3848-3852

Separation of fluorescein isothiocyanate-labeled amines by microchip electrophoresis in uncoated and polyvinyl alcohol-coated glass chips using water and dimethyl sulfoxide as solvents of background electrolyte
S.J.O. Varjo, M. Ludwig, D. Belder, M.L. Riekkola, Electrophoresis 2004, 25, 1901-1906

2003

Surface modification in microchip electrophoresis
D. Belder, M. Ludwig, Electrophoresis 2003, 24, 3595-3606

High-speed chiral separations on a microchip with UV detection
M. Ludwig, F. Kohler, D. Belder, Electrophoresis 2003, 24, 3233-3238

Microchip electrophoresis for chiral separations
D. Belder, M. Ludwig, Electrophoresis 2003, 24, 2422-2430

Coated microfluidic devices for improved chiral separations in microchip electrophoresis
M. Ludwig, D. Belder, Electrophoresis 2003, 24, 2481-2486

 

2002

Poly(vinyl alcohol)-coated microfluidic devices for high-performance microchip electrophoresis
D. Belder,  A. Deege, F. Kohler, M. Ludwig, Electrophoresis 2002, 23, 3567-3573

Design and performance of a microchip electrophoresis instrument with sensitive variable-wavelength fluorescence detection
D. Belder,  A. Deege,  M. Maass, M. Ludwig, Electrophoresis 2002, 23, 2355-2361

 

 

 

 

letzte Änderung: 07.09.2017