Publikationen

Gemeinsame Publikationen (peer reviewed)

2018

Z. Zhang, U. Gernert, R. Gerhardt, E.-M. Höhn, D. Belder, J. Kneipp
Catalysis by Metal Nanoparticles in a Plug-in Optofluidic Platform: Redox Reactions of p-Nitrobenzenethiol and p-Aminothiophenol
ACS Catal. 2018, 8, 2443-2449.

J. Appun, F. Stolz, S. Naumov, B. Abel, C. Schneider
Modular Synthesis of Dipyrroloquinolines – A Combined Synthetic and Mechanistic Study
JOC 2018, 83, 1737-1744.

S. Zernia, R. Frank, R. H. J. Weiße, H. G. Jahnke, K. Bellmann-Sickert, A. Prager, B. Abel, N. Sträter, A. Robitzki, A. G. Beck-Sickinger
Surface-Binding Peptide Facilitates Electricity-Driven NADPH-Free Cytochrome P450 Catalysis
ChemCatChem. 2018, 10, 525-530.

S. A. Pfeiffer, B. M. Rudisch, P. Glaeser, M. Spanka, F. Nitschke, A. A. Robitzki, C. Schneider, S. Nagl, D. Belder
Continuous purification of reaction products by micro free-flow electrophoresis enabled by large area deep-UV fluorescence imaging
Anal. Bioanal. Chem. 2018, 410, 853-862.
________________________________________________________________________________

2017

F. D. Zitzmann, H. G. Jahnke, S. A. Pfeiffer, R. Frank, F. Nitschke, L. Mauritz, B. Abel, D. Belder, A. A. Robitzki
Microfluidic Free-Flow Electrophoresis Based Solvent Exchanger for Continuously Operating Lab-on-Chip Applications
Anal. Chem. 2017, 89, 13550–13558.

F. Zitzmann, H. G. Jahnke, F. Nitschke, A. G. Beck-Sickinger, B. Abel, D. Belder, A. Robitzki
A novel microfluidic microelectrode chip for a significantly enhanced monitoring of NPY-receptor activation in live mode
Lab Chip 2017, 17, 4294-4302.

S. Schulze, M. Pahl, F. Stolz, J. Appun, B. Abel, C. Schneider, D. Belder
Liquid beam desorption mass spectrometry for the investigation of continuous flow reactions in microfluidic chips
Anal. Chem. 2017, 89, 6175–6181.

J. Appun, M. Boomhoff, P. Hoffmeyer, I. Kallweit, M. Pahl, D. Belder,
C. Schneider
A Highly Stereoselective Synthesis of Tetrahydrofurans
Angew. Chem. Int. Ed. 2017, 24, 6862-6865.

J. R. Beulig, R. Warias, J. J. Heiland, S. Ohla, K. Zeitler, D. Belder
A droplet-chip / mass spectrometry approach to study organic synthesis at nanoliter scale
Lab Chip 2017, 17, 1996-2002.

J. J. Heiland, R. Warias, C. Lotter, P. Fuchs, L. Mauritz, K. Zeitler,
S. Ohla, D. Belder
On-chip integration of organic synthesis and HPLC/MS analysis for monitoring stereoselective transformations at the micro-scale
Lab Chip 2017, 17, 76-81.

D. Geissler, J. J. Heiland, C. Lotter, D. Belder
Microchip HPLC separations monitored simultaneously by coherent anti-Stokes Raman scattering and fluorescence detection
Microchim Acta 2017, 184, 315-321.

F. Stolz, J. Appun, S. Naumov, C. Schneider, B. Abel
A Complex Catalytic Reaction Caught in the Act: Intermediates and Products Sampling Online by Liquid µ-Beam Mass Spectrometry and Theoretical Modeling
ChemPlusChem 2017, 82, 233-240.

_________________________________________________________________________________

2016

C. Dietze, S. Schulze, S. Ohla, K. Gilmore, P. Seeberger, D. Belder
Integrated on-chip mass spectrometry reaction monitoring in microfluidic devices containing porous polymer monolithic columns
Analyst 2016, 141, 5412-5416.

S. Zernia, F. Ott, K. Bellmann-­Sickert, R. Frank, M. Klenner, H. G. Jahnke, A. Prager, B. Abel, A. Robitzki, A. G. Beck-­Sickinger
Peptide-Mediated Specific Immobilization of Catalytically Active Cytochrome P450 BM3 Variant
Bioconjugate Chem. 2016, 27, 1090-1097.

____________________________________________________________________________________

2015

C. Dietze, T. Scholl, S. Ohla, J. Appun, C. Schneider, D. Belder
Rapid prototyping of microfluidic chips for dead-volume-free MS coupling
Anal. Bioanal. Chem. 2015, 407, 8735-8743.

T. A. Meier, E. Poehler, F. Kemper, O. Pabst, H. G. Jahnke, E. Beckert,
A. Robitzki, D. Belder
Fast electrically assisted regeneration of on chip SERS substrates
Lab Chip 2015, 15, 2923-2927.

C. Benz, M. Boomhoff, J. Appun, C. Schneider, D. Belder
Chip-Based Free-Flow Electrophoresis with Integrated Nanospray Mass-Spectrometry
Angew. Chem. Int. Ed. 2015, 54, 2766-2770.

C. Höra, S. Ohla, Z. Shu, E. Beckert, S. Nagl, D. Belder
An integrated microfluidic chip enabling control and spatially resolved monitoring of temperature in micro flow reactors
Anal. Bioanal. Chem. 2015, 407, 387-396.

Projektbezogene Publikationen

Projekt 1

J. R. Beulig, R. Warias, J. J. Heiland, S. Ohla, K. Zeitler, D. Belder
A droplet-chip / mass spectrometry approach to study organic synthesis at nanoliter scale
Lab Chip 2017, 17, 1996-2002.

J. J. Heiland, R. Warias, C. Lotter, P. Fuchs, L. Mauritz, K. Zeitler,
S. Ohla, D. Belder
On-chip integration of organic synthesis and HPLC/MS analysis for monitoring stereoselective transformations at the micro-scale
Lab Chip 2017, 17, 76-81.

J. Appun, M. Boomhoff, P. Hoffmeyer, I. Kallweit, M. Pahl, D. Belder,
C. Schneider
A Highly Stereoselective Synthesis of Tetrahydrofurans
Angew. Chem. Int. Ed. 2017, 24, 6862-6865.

C. Dietze, S. Schulze, S. Ohla, K. Gilmore, P. Seeberger, D. Belder
Integrated on-chip mass spectrometry reaction monitoring in microfluidic devices containing porous polymer monolithic columns
Analyst 2016, 141, 5412-5416.

AK. M. Krone, R. Warias, C. Ritter, A. Li, C. G. Acevedo-Rocha, M. T. Reetz, D. Belder
Analysis of Enantioselective Biotransformations Using a Few Hundred Cells on an Integrated Microfluidic Chip
JACS 2016, 138, 2102–2105.

C. Lotter, E. Poehler, J. J. Heiland, L. Mauritz, D. Belder
Enantioselective reaction monitoring utilizing two-dimensional heart-cut liquid chromatography on an integrated microfluidic chip
Lab Chip 2016, 16, 4648-4652.

C. Dietze, T. Scholl, S. Ohla, J. Appun, C. Schneider, D. Belder
Rapid prototyping of microfluidic chips for dead-volume-free MS coupling
Anal. Bioanal. Chem. 2015, 407, 8735-8743.
__________________________________________________________________________________

Projekt 2

H. S. Hahm, M. K. Schlegel, M. Hurevich, S. Eller, F. Schuhmacher,
J. Hofmann, K. Pagel, P. H. Seeberger
Automated glycan assembly using the Glyconeer 2.1 synthesizer
Proc. Natl. Acad. Sci. U.S.A. 2017, 114, E3385-E3389.

C. Dietze, S. Schulze, S. Ohla, K. Gilmore, P. Seeberger, D. Belder
Integrated on-chip mass spectrometry reaction monitoring in microfluidic devices containing porous polymer monolithic columns
Analyst 2016, 141, 5412-5416.

J. Hofmann, H. S. Hahm, P. H. Seeberger, K. Pagel
Identification of carbohydrate anomers using ion mobility-mass spectrometry
Nature 2015, 526, 241-244.
_________________________________________________________________________________

Projekt 3

Z. Zhang, U. Gernert, R. Gerhardt, E.-M. Höhn, D. Belder, J. Kneipp
Catalysis by Metal Nanoparticles in a Plug-in Optofluidic Platform: Redox Reactions of p-Nitrobenzenethiol and p-Aminothiophenol
ACS Catal. 2018, 8, 2443-2449.

J. Kneipp
Interrogating Cells, Tissues, and Live Animals with New Generations of Surface-Enhanced Raman Scattering Probes and Labels
ACS Nano 2017, 11, 1136–1141.
________________________________________________________________________________

Projekt 4

J. Appun, F. Stolz, S. Naumov, B. Abel, C. Schneider
Modular Synthesis of Dipyrroloquinolines – A Combined Synthetic and Mechanistic Study
JOC 2018, 83, 1737-1744.

S. A. Pfeiffer, B. M. Rudisch, P. Glaeser, M. Spanka, F. Nitschke, A. Robitzki,
C. Schneider, S. Nagl, D. Belder
Continuous purification of reaction products by micro free-flow electrophoresis enabled by large area deep-UV fluorescence imaging
Anal. Bioanal. Chem. 2018, 410, 853-862.

J. Appun, M. Boomhoff, P. Hoffmeyer, I. Kallweit, M. Pahl, D. Belder,
C. Schneider
A highly stereoselective synthesis of tetrahydrofurans
Angew. Chem. 2017, 129, 6862-6865.

S. Schulze, M. Pahl, F. Stolz, J. Appun, B. Abel, C. Schneider, D. Belder
Liquid beam desorption mass spectrometry for the investigation of continuous flow reactions in microfluidic chips
Anal. Chem. 2017, 89, 6175-6181.

F. Stolz, J. Appun, S. Naumov, C. Schneider, B. Abel
A Complex Catalytic Reaction Caught in the Act: Intermediates and Products Sampling Online by Liquid µ-Beam Mass Spectrometry and Theoretical Modeling
ChemPlusChem 2017, 82, 233-240.

C. Dietze, T. Scholl, S. Ohla, J. Appun, C. Schneider, D. Belder
Rapid prototyping of microfluidic chips for dead-volume-free MS coupling
Anal. Bioanal. Chem. 2015, 407, 8735-8743.
_________________________________________________________________________________

Projekt 5

J. Appun, F. Stolz, S. Naumov, B. Abel, C. Schneider
Modular Synthesis of Dipyrroloquinolines – A Combined Synthetic and Mechanistic Study
JOC 2018, 83, 1737-1744.

F. Stolz, J. Appun, S. Naumov, C. Schneider, B. Abel
A Complex Catalytic Reaction Caught in the Act: Intermediates and Products Sampling Online by Liquid µ-Beam Mass Spectrometry and Theoretical Modeling
ChemPlusChem 2017, 82, 233-240.

S. Schulze, M. Pahl, F. Stolz, J. Appun, B. Abel, C. Schneider, D. Belder
Liquid beam desorption mass spectrometry for the investigation of continuous flow reactions in microfluidic chips

Anal. Chem. 2017, 89, 6175–6181.
_________________________________________________________________________________

Projekt 6

S. A. Pfeiffer, B. M. Rudisch, P. Glaeser, M. Spanka, F. Nitschke, A. Robitzki,
C. Schneider, S. Nagl, D. Belder
Continuous purification of reaction products by micro free-flow electrophoresis enabled by large area deep-UV fluorescence imaging
Anal. Bioanal. Chem. 2018, 410, 853-862.

F. D. Zitzmann, H. G. Jahnke, S. A. Pfeiffer, R. Frank, F. Nitschke, L. Mauritz, B. Abel, D. Belder, A. A. Robitzki
Microfluidic Free-Flow Electrophoresis Based Solvent Exchanger for Continuously Operating Lab-on-Chip Applications
Anal. Chem. 2017, 89, 13550–13558.

R. Frank, M. Klenner, F. D. Zitzmann, S. Schmidt, H. G. Jahnke,
A. A. Robitzki
Electrochemical restructuring of thin layer indium tin oxide electrode arrays for optimized (bio)electrocatalysis
Electrochim. Acta 2017, 259, 449-457.

F. Zitzmann, H. G. Jahnke, F. Nitschke, A. G. Beck-Sickinger, B. Abel,
D. Belder, A. Robitzki
A novel microfluidic microelectrode chip for a significantly enhanced monitoring of NPY-receptor activation in live mode

Lab Chip 2017, 17, 4294-4302.

M. Weyer, H.-G. Jahnke, D. Krinke, F. D. Zitzmann, K. Hill, M. Schaefer,
A. A. Robitzki
Quantitative characterization of capsaicin-induced TRPV1 ion channel activation in HEK293 cells by impedance spectroscopy
Anal. Bioanal Chem. 2016, 408, 8529-8538.

T. A. Meier, E. Poehler, F. Kemper, O. Pabst, H. G. Jahnke, E. Beckert,
A. Robitzki, D. Belder
Fast electrically assisted regeneration of on chip SERS substrates
Lab Chip 2015, 15, 2923-2927.
__________________________________________________________________________________

Projekt 7

S. A. Pfeiffer, B. M. Rudisch, P. Glaeser, M. Spanka, F. Nitschke, A. A. Robitzki, C. Schneider, S. Nagl, D. Belder
Continuous purification of reaction products by micro free-flow electrophoresis enabled by large area deep-UV fluorescence imaging
Anal. Bioanal. Chem. 2018, 410, 853-862.

S. Schulze, M. Pahl, F. Stolz, J. Appun, B. Abel, C. Schneider, D. Belder
Liquid beam desorption mass spectrometry for the investigation of continuous flow reactions in microfluidic chips

Anal. Chem. 2017, 89, 6175–6181.

J. Appun, M. Boomhoff, P. Hoffmeyer, I. Kallweit, M. Pahl, D. Belder,
C. Schneider
A Highly Stereoselective Synthesis of Tetrahydrofurans
Angew. Chem. Int. Ed. 2017, 24, 6862-6865.

S. A. Pfeiffer, S. M. Borisov, S. Nagl
In-line monitoring of pH and oxygen during enzymatic reactions in off-the-shelf all-glass microreactors using integrated luminescent microsensors

Microchimica Acta 217; 184, 621-626.

E. Poehler, S. A. Pfeiffer, M. Herm, M. Gaebler, B. Busse, S. Nagl
Microchamber arrays with an integrated long luminescence lifetime pH sensor
Anal. Bioanal. Chem. 2016, 408, 2927-2935.

C. Herzog, E. Poehler, A. J. Peretzki, S. M. Borisov, D. Aigner, T. Mayr,
S. Nagl
Continuous on-chip fluorescence labelling, free-flow isoelectric focusing and marker-free isoelectric point determination of proteins and peptides
Lab Chip 2016, 16, 1565-1572.

E. Poehler, C. Herzog, S. A. Pfeiffer, C. Lotter, A. J. Peretzki, D. Aigner, T. Mayr,  E. Beckert, S. Nagl
Application of Optical pH Sensors in the Microfluidic Free-flow Isoelectric Focusing of Biomolecules
Proc. Eng. 2015, 120, 175-179.
_______________________________________________________________________________

Projekt 8

P. Fuchs, K. Zeitler
An N-Heterocyclic Carbene-mediated, enantioselective and multicatalytic strategy to access dihydropyranones in a sequential three-component onepot reaction
Org. Lett. 2017, 19, 6076–6079.

J. R. Beulig, R. Warias, J. J. Heiland, S. Ohla, K. Zeitler, D. Belder
A droplet-chip / mass spectrometry approach to study organic synthesis at nanoliter scale
Lab Chip 2017, 17, 1996-2002.

J. J. Heiland , R. Warias , C. Lotter , P. Fuchs , L. Mauritz , K. Zeitler,
S. Ohla, D. Belder
On-chip integration of organic synthesis and HPLC/MS analysis for monitoring stereoselective transformations at the micro-scale
Lab Chip 2017, 17, 76-81.

E. Speckmeier, K. Zeitler
Desyl and Phenacyl as Versatile, Photocatalytically Cleavable Protecting Groups - A Classic Approach in a Different (Visible) Light
ACS Catal. 2017, 7, 6821-6826.

P. Fuchs, K. Zeitler
Nitroalkenes as latent 1,2-biselectrophiles – A multicatalytic approach for the synthesis of 1,4-diketones and their application in a 4-step one-pot reaction to polysubstituted pyrroles
J. Org. Chem. 2017, 82, 7796-7805.

C. Selg, W. Neumann, P. Lönnecke, E. Hey-Hawkins, Evamarie, K. Zeitler
Carboranes as Aryl Mimetics in Catalysis: A Highly Active Zwitterionic NHC-Precatalyst
Chem. Eur. J. 2017, 23, 7932-7937.

J. F. Franz, W. B. Kraus, K. Zeitler
No Photocatalyst Required – Versatile, Visible Light Mediated Transformations with Polyhalomethanes
Chem. Commun. 2015, 51, 8280-8283.

E. Speckmeier, C. Padié, K. Zeitler
Visible Light Mediated Reductive Cleavage of C–O Bonds Accessing α-Substituted Aryl Ketones
Org. Lett. 2015, 17, 4818-4821.
____________________________________________________________________________________

Projekt 9

F. Zitzmann, H. G. Jahnke, F. Nitschke, A. G. Beck-Sickinger, B. Abel,
D. Belder, A. Robitzki
A novel microfluidic microelectrode chip for a significantly enhanced monitoring of NPY-receptor activation in live mode

Lab Chip 2017, 17, 4294-4302.

F. D. Zitzmann, H. G. Jahnke, S. A. Pfeiffer, R. Frank, F. Nitschke, L. Mauritz, B. Abel, D. Belder, A. A. Robitzki
Microfluidic Free-Flow Electrophoresis Based Solvent Exchanger for Continuously Operating Lab-on-Chip Applications
Anal. Chem. 2017, 89, 13550–13558.

S. A. Pfeiffer, B. M. Rudisch, P. Glaeser, M. Spanka, F. Nitschke, A. A. Robitzki, C. Schneider, S. Nagl, D. Belder
Continuous purification of reaction products by micro free-flow electrophoresis enabled by large area deep-UV fluorescence imaging
Anal. Bioanal. Chem. 2017, 410, 853-862.

S. Schulze, M. Pahl, F. Stolz, J. Appun, B. Abel, C. Schneider, D. Belder
Liquid beam desorption mass spectrometry for the investigation of continuous flow reactions in microfluidic chips

Anal. Chem. 2017, 89, 6175–6181.

J. Appun, M. Boomhoff, P. Hoffmeyer, I. Kallweit, M. Pahl, D. Belder,
C. Schneider
A Highly Stereoselective Synthesis of Tetrahydrofurans
Angew. Chem. Int. Ed. 2017, 24, 6862-6865.

J. R. Beulig, R. Warias, J. J. Heiland, S. Ohla, K. Zeitler, D. Belder
A droplet-chip / mass spectrometry approach to study organic synthesis at nanoliter scale
Lab Chip 2017, 17, 1996-2002.

J. J. Heiland, C. Lotter, V. Stein, L. Mauritz, D. Belder
Temperature gradient elution and superheated eluents in chip-HPLC
Anal. Chem. 2017, 89, 3266-3271.

J. J. Heiland , R. Warias , C. Lotter , P. Fuchs , L. Mauritz , K. Zeitler,
S. Ohla, D. Belder
On-chip integration of organic synthesis and HPLC/MS analysis for monitoring stereoselective transformations at the micro-scale
Lab Chip 2017, 17, 76-81.

D. Geissler, J. J. Heiland, C. Lotter, D. Belder
Microchip HPLC separations monitored simultaneously by coherent anti-Stokes Raman scattering and fluorescence detection
Microchim Acta 2017, 184, 315-321.

S. Zernia, F. Ott, K. Bellmann-­Sickert, R. Frank, M. Klenner, H. G. Jahnke, A. Prager, B. Abel, A. Robitzki, A. G. Beck-­Sickinger
Peptide-Mediated Specific Immobilization of Catalytically Active Cytochrome P450 BM3 Variant
Bioconjugate Chem. 2016, 27, 1090-1097.

C. Dietze, S. Schulze, S. Ohla, K. Gilmore, P. Seeberger, D. Belder
Integrated on-chip mass spectrometry reaction monitoring in microfluidic devices containing porous polymer monolithic columns
Analyst 2016, 141, 5412-5416.

K. M. Krone, R. Warias, C. Ritter, A. Li, C. G. Acevedo-Rocha, M. T. Reetz,
D. Belder
Analysis of Enantioselective Biotransformations Using a Few Hundred Cells on an Integrated Microfluidic Chip

JACS 2016, 138, 2102–2105.

T. Büchner, D. Drescher, V. Merk, H. Traub, P. Guttmann, S. Werner, N. Jakubowski, G. Schneider, J. Kneipp
Biomolecular environment, quantification, and intracellular interaction of multifunctional magnetic SERS nanoprobes
Analyst 2016, 141, 5096-5106.

D. Bartkowiak, V. Merk, V. Reiter-Scherer, U. Gernert, J. P. Rabe, J. Kneipp, E. Kemnitz
Porous MgF2-over-gold nanoparticles (MON) as plasmonic substrate for analytical applications
RSC Advances 2016, 6, 71557-71566.

Weyer M, Jahnke HG, Krinke D, Zitzmann FD, Hill K, Schaefer M, Robitzki AA
Quantitative characterization of capsaicin-induced TRPV1 ion channel activation in HEK293 cells by impedance spectroscopy
Anal Bioanal Chem. 2016, 408, 8529-8538.

C. Lotter, E. Poehler, J. J. Heiland, L. Mauritz, D. Belder
Enantioselective reaction monitoring utilizing two-dimensional heart-cut liquid chromatography on an integrated microfluidic chip
Lab Chip 2016, 16, 4648-4652.

C. Lotter, J. J. Heiland, V. Stein, M. Klimkait, M. Queisser, D. Belder
Evaluation of Pressure Stable Chip-to-Tube Fittings Enabling High-Speed Chip-HPLC with Mass Spectrometric Detection
Anal. Chem. 2016, 88, 7481–7486.

C. Dietze, C. Hackl, R. Gerhardt, S. Seim, D. Belder
Chip-based electrochromatography coupled to ESI-MS detection

Electrophoresis 2016, 37, 1345-1352.

C. Lotter, J. J. Heiland, S. Thurmann, L. Mauritz, D. Belder
HPLC-MS with Glass Chips Featuring Monolithically Integrated Electrospray Emitters of Different Geometries
Anal. Chem. 2016, 88, 2856–2863.

C. Hoera, M. M. Skadell, S. A. Pfeiffer, M. Pahl, Z. Shu, E. Beckert, D. Belder
A chip-integrated highly variable thermal flow rate sensor
Sensors and Actuators B: Chemical 2016, 225, 42-49.

C. Dietze, T. Scholl, S. Ohla, J. Appun, C. Schneider, D. Belder
Rapid prototyping of microfluidic chips for dead-volume-free MS coupling
Anal. Bioanal. Chem. 2015, 407, 8735-8743.

C. Höra, S. Ohla, Z. Shu, E. Beckert, S. Nagl, D. Belder
An integrated microfluidic chip enabling control and spatially resolved monitoring of temperature in micro flow reactors
Anal. Bioanal. Chem. 2015, 407, 387-396.

letzte Änderung: 06.03.2018